A simple way to enhance Doxil® therapy: Drug release from liposomes at the tumor site by amphiphilic block copolymer

Amphiphilic Block Copolymer Nano-micelles: Effect of Length Ratio of the Hydrophilic Block

Block copolymer nano-micelles are especially important in cancer treatment because of their fine dimensions. In this article, three systems of amphiphilic copolymers with similar lengths and different ratios of the hydrophobic and hydrophilic chains are studied using implicit-solvent coarse-grained molecular dynamics simulations. The factor fphil is defined as the ratio of the number...

Amphiphilic Block Copolymer Micelles for Drug Delivery Vehicles

Amphiphilic block copolymer micelles have been the focus of research for the last decades because of the promising properties as nano size drug delivery vehicles. In polar aqueous milieu, copolymers self assemble into micelle structures which consist of hydrophilic corona and hydrophobic core regions. Space created inside the micelle core can be used for transportation of drug molecules of hydr...

Evaluation of drug release from Abraxane and Doxil in tumor tissue

Preparation of Temperature-sensitive Liposomes for Delivery of Anticancer Drugs by Use of Thermosensitive Amphiphilic Block Copolymer

ANTICANCER DRUGS BY USE OF THERMOSENSITIVE AMPHIPHILIC BLOCK COPOLYMER Kenji Kono, Toshiaki Ozawa, Chie Kojima, Atsushi Harada, Shokyoku Kanaoka, Sadahito Aoshima, Kazuo Maruyama, and Yukihito Ishizaka Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai, Osaka 5998531, Japan Department of Macromolecular Science, Graduate S...

amphiphilic block copolymer nano-micelles: effect of length ratio of the hydrophilic block

block copolymer nano-micelles are especially important in cancer treatment because of their fine dimensions. in this article, three systems of amphiphilic copolymers with similar lengths and different ratios of the hydrophobic and hydrophilic chains are studied using implicit-solvent coarse-grained molecular dynamics simulations. the factor fphil is defined as the ratio of the number of hydroph...